منابع مشابه
Molecular determinants of the functional interaction between syntaxin and N-type Ca2+ channel gating.
Syntaxin is a key presynaptic protein that binds to N- and P/Q-type Ca(2+) channels in biochemical studies and affects gating of these Ca(2+) channels in expression systems and in synaptosomes. The present study was aimed at understanding the molecular basis of syntaxin modulation of N-type channel gating. Mutagenesis of either syntaxin 1A or the pore-forming alpha(1B) subunit of N-type Ca(2+) ...
متن کاملCa2+ entry-independent effects of L-type Ca2+ channel modulators on Ca2+ sparks in ventricular myocytes.
During the cardiac action potential, Ca(2+) entry through dyhidropyridine receptor L-type Ca(2+) channels (DHPRs) activates ryanodine receptors (RyRs) Ca(2+)-release channels, resulting in massive Ca(2+) mobilization from the sarcoplasmic reticulum (SR). This global Ca(2+) release arises from spatiotemporal summation of many localized elementary Ca(2+)-release events, Ca(2+) sparks. We tested w...
متن کاملA sympathetic model of L-type Ca2+ channel-triggered arrhythmias.
L-TYPE CA2 CHANNELS PLAY a pivotal role in regulating cellular excitability and contractility in cardiac tissue. Ca influx through these channels [L-type Ca current (ICa,L)] contributes to the plateau phase of the ventricular action potential and initiates excitation-contraction coupling by activating Ca release channels or ryanodine receptors in the sarcoplasmic reticulum (1). The resulting Ca...
متن کاملSingle-Channel Demonstration of L-Type Ca2+ Window Current
Canine cardiac Purkinje cells contain both Land T-type calcium currents, yet the single Ca2' channels have not been characterized from these cells. Additionally, previous studies have shown an overlap between the steady-state inactivation and activation curves for L-type Ca2' currents, suggesting the presence of L-type Ca2' "window" current. We used the on-cell, patch-clamp technique to study C...
متن کاملCav1.3 (CACNA1D) L‐type Ca2+ channel dysfunction in CNS disorders
Cav 1.3 belongs to the family of voltage-gated L-type Ca2+ channels and is encoded by the CACNA1D gene. Cav 1.3 channels are not only essential for cardiac pacemaking, hearing and hormone secretion but are also expressed postsynaptically in neurons, where they shape neuronal firing and plasticity. Recent findings provide evidence that human mutations in the CACNA1D gene can confer risk for the ...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2003
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.121.211